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Richard D. Moore, MD; Craig R. Smith, MD; Paul S. Lietman, MD, PhD
The Johns Hopkins Hospital Baltimore

JAMA. 1986;256(7):864-865.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

We wish to offer several comments concerning the publication by Lam and collegues.¹

1. Since publication of our study,² we have applied our discriminant function prospectively to 143 sequential medical and surgical patients (no exclusions) hospitalized at Johns Hopkins. Plots of the distributions of the discriminant sums and the associated probabilities of nephrotoxicity for the patients who did and did not develop nephrotoxicity are shown in Fig 1. Using these data, the sensitivity, specificity, and predictive values of our discriminant function can be determined for any selected classification cutoff point. For example, using a cutoff point of 0.75 (0.25 probability) to define a positive test result, the following table is generated:
   

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