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Douglas M. Ackermann, MD; Brooks S. Edwards, MD; Lester E. Wold, MD; John C. Burnette, Jr, MD

JAMA. 1986;256(8):1048.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Atrial natriuretic peptide (ANP) is a newly recognized hormone that has important function both in the physiologic and pathophysiologic regulation of extracellular volume. The predominant actions of ANP include (1) promotion of sodium and water excretion and an increase in glomerular filtration rate, (2) inhibition of renin secretion and aldosterone synthesis, and (3) reduction in systemic arterial pressure. The hormone is synthesized within the myocardial cells of both cardiac atria and stored in membrane-bound secretory granules located predominantly in a perinuclear position (Figure).

It has long been recognized that the atria participate in both sensing and regulating intravascular volume.¹ In 1963, the eminent British cardiologist Dr Paul Wood² reported on the association between paroxysmal atrial tachycardia (PAT) and polyuria. Wood described a population of patients with PAT in whom, coincident with the tachycardia, polyuria developed. The existence of a humoral agent of cardiac origin, which is capable of . . . [Full Text PDF of this Article]

Author Affiliations
Mayo Medical School Rochester, Minn

Footnotes
Reprint requests to Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Medical School, Rochester, MN 55905 (Dr Edwards).

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