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Correlation Between Biochemical Indicators of Lead Exposure and Semen Quality in a Lead-Poisoned Firearms Instructor
Jocheved Fisher-Fischbein, PhD;
Alf Fischbein, MD;
Hugh D. Melnick, MD;
C. Wayne Bardin, MD
JAMA. 1987;257(6):803-805.
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LEAD poisoning is a disease of great public health concern, particularly because of the hazards that lead can pose to children as a result of ingestion of lead-based paint and perhaps as a consequence of the effects of lead pollution of the ambient air.1
However, lead poisoning is also a common occupational disease among adults.2 Groups at high risk of developing this disorder include smelter workers,3 workers engaged in flame cutting of lead-painted iron and steel structures,4 and arts and craft workers. Persons who work as instructors at indoor firing ranges are likewise at high risk for occupational lead poisoning.5 The typical biochemical features of lead poisoning include inhibition of heme synthesis manifested by elevated levels of erythrocyte protoporphyrin (free erythrocyte protoporphyrin and zinc protoporphyrin [ZPP]) and decreased activity of  -aminolevulinic acid dehydratase.6,7 Common symptoms are nonspecific neurologic symptoms (eg, headache, dizziness, fatigue, and sleep
. . . [Full Text PDF of this Article]
Author Affiliations
From the Population Council, Center for Biomedical Research (Drs Fisher-Fischbein and Bardin), Division of Environmental and Occupational Medicine, Mount Sinai School of Medicine of the City University of New York (Dr Fischbein), and Advanced Fertility Services Inc (Drs Fisher-Fischbein and Melnick), New York.
Footnotes
Reprint requests to Division of Environmental and Occupational Medicine, Mount Sinai School of Medicine, One Gustave L. Levy PI, New York, NY 10029 (Dr Fischbein).
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