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Disseminated Intravascular Coagulation in Prostatic Carcinoma Reversed by Ketoconazole
Marc R. Litt, MD;
William R. Bell, MD;
Herbert A. Lepor, MD
JAMA. 1987;258(10):1361-1362.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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DISSEMINATED intravascular coagulation (DIC) is a well-recognized complication of malignant neoplasms. Between 13% and 25% of the patients with chronic DIC have underlying prostatic carcinoma.1,2 The mechanism of DIC in these patients appears to be related to release of thromboplastins from prostatic tissue.3
The treatment of DIC involves prompt identification, with control or eradication of the underlying disease process. Correction of circulatory volume, hemostatic elements, and possible sepsis is mandatory. The use of heparin sodium (Panheparin),  -aminocaproic acid, and exogenous estrogens in DIC related to prostatic carcinoma remains controversial.4
The following report describes the use of ketoconazole in the treatment and reversal of DIC associated with prostatic carcinoma.
Report of a Case
An 82-year-old man with metastatic prostatic cancer was transferred to The Johns Hopkins Hospital, Baltimore, for evaluation of a coagulopathy and hematuria. Two years previously, the patient developed symptoms of urinary obstruction and underwent a
. . . [Full Text PDF of this Article]
Author Affiliations
From the Departments of Medicine (Drs Litt and Bell) and Urology (Dr Lepor), The Johns Hopkins University School of Medicine and Hospital, Baltimore.
Footnotes
Reprint requests to Department of Medicine, The Johns Hopkins University School of Medicine and Hospital, 600 N Wolfe St, Baltimore, MD 21205 (Dr Bell).
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