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Stephan D. Fihn, MD, MPH

JAMA. 1987;258(17):2416-2418.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Concern about serum cholesterol has become a national preoccupation. Recently, this pernicious substance has received even greater attention after announcement of the recommendations of the National Cholesterol Education Program.¹ This initiative represents the culmination of four decades of epidemiologic research that has demonstrated a nearly monotonic relationship between elevations of the serum cholesterol level and risk of atherosclerotic heart disease. Until recently, however, it was uncertain whether lowering of the serum cholesterol level would also lower cardiac risk. The results of the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) now confirm that in men with substantial elevations of plasma cholesterol levels, dietary and drug intervention can indeed reduce coronary morbidity and mortality.²

The LRC-CPPT data, viewed as the linchpin in the cholesterol-coronary chain of evidence, have served as the catalyst for the National Cholesterol Education Program. The recommendations advise frequent screening of most adults and treatment of . . . [Full Text PDF of this Article]

Author Affiliations
Seattle Veterans Administration Medical Center

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