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Larry E. Millikan, MD

JAMA. 1987;258(20):2910-2915.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WISE et al¹ first explored the realm of cutaneous immunofluorescence in 1962. After these initial steps, the landmark work of Beutner and Jordon² in the early '60s rapidly moved forward the diagnostic utility of cutaneous immunofluorescence and advanced our knowledge of the various vesiculobullous skin diseases, in which immunoreactants are demonstrated and thought to play a significant role. Even more sophisticated techniques have been developed that now provide remarkable insight into the anatomy of the dermal-epidermal structures and their interface and also provide insight into pathogenesis of these diseases and therapeutic potential for them. Since the last review of this situation in 1982, many advances have occurred in our understanding of the dermal-epidermal interface and pathophysiology of the mechanobullous or vesiculobullous diseases. This section updates our understanding of diseases previously covered (pemphigus, pemphigoid, dermatitis herpetiformis, chronic bullous dermatosis of childhood, and herpes gestationis) and adds an overview of . . . [Full Text PDF of this Article]

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