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Mitchell H. Friedlaender, MD

JAMA. 1987;258(20):2916-2919.

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THE EYE may be the target of allergic inflammation in a variety of systemic immunologic conditions. Ocular signs and symptoms can often be the most striking and disabling aspects of such diseases. The eye also is affected by several local conditions in which immunologic mechanisms are thought to play a significant role. Major structures of the eye are illustrated in Fig 10-1. Immunologically mediated diseases of the skin and mucous membranes, the cornea, and the uveal tract and retina are discussed in the following sections.

DISEASES OF THE SKIN AND MUCOUS MEMBRANES OF THE EYE Allergic Conjunctivitis

Many patients with allergic rhinitis have red, itchy, watery eyes. This form of conjunctivitis, known simply as allergic conjunctivitis, is an IgE-mediated reaction in which conjunctival mast cells participate. As in allergic rhinitis, preformed mediators such as histamine are released from mast-cell cytoplasmic granules while arachidonic acid metabolites (prostaglandins and leukotrienes) are synthesized . . . [Full Text PDF of this Article]

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