This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Karl Verebey, PhD
New York State Division of Substance Abuse Brooklyn

Jamyl Alrazi
Psychiatric Diagnostic Laboratories of America South Plainfield, NJ

Jerome H. Jaffe, MD
National Institute on Drug Abuse Baltimore

JAMA. 1988;259(11):1649-1650.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Drs Brown and Osterloh,¹ in a recent letter in THE JOURNAL, reported a nearly fatal toxic reaction to 3,4-methylenedioxymethamphetamine (MDMA). The estimated dose of MDMA administered was 100 to 150 mg and the blood levels, measured at one and two hours after hospital admission, were 6500 and 7000 ng/mL, respectively.

Before MDMA became a Schedule 1 drug on July 1, 1985,² it was used in doses of 100 to 150 mg by some psychiatrists who claimed that it was effective as a psychotropic catalyst and a sensory disinhibitor; at these doses, no toxic effects were reported. (The experiment was performed on March 12, 1985, before the scheduling of MDMA and was carried out by one of us [J.A.] in partial requirement for the degree of Doctor of Physiology.) At that time, we carried out a controlled study of MDMA metabolism and disposition in a single . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?