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Altered Folate Metabolism in Early HIV Infection
Richard S. Beach, MD, PhD;
Emilio Mantero-Atienza, MD;
Carl Eisdorfer, MD, PhD;
Marianna K. Fordyce-Baum, PhD
University of Miami School of Medicine
JAMA. 1988;259(4):519.
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To the Editor.
—We are currently conducting a longitudinal study of various biologic, psychological, and social factors in the progression of human immunodeficiency virus (HIV) infection in 100 male homosexuals between the ages of 20 and 45 years. These men have HIV infection confirmed by the Western blot technique; the only symptoms are lymphadenopathy (Centers for Disease Control stage 3). Initial determinations have shown significantly elevated plasma and erythrocyte folate levels as determined by microbiological assay.1 Fifty-eight percent of HIV-infected individuals had plasma folate values above the normal range, the first 24 subjects having a mean plasma folate level of 22.0 ± 1.40 nmol/L (9.71 ± 0.62 ng/mL). Three hundred health professionals used as controls had serum folate levels varying between 4.53 and 22.66 nmol/L (2 and 10 ng/mL) (P<.005). Seventy-five percent of the participants had erythrocyte folate levels above normal, with a mean in the HIV-infected subjects
. . . [Full Text PDF of this Article]
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