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Long-term Treatment of Acute Deep Venous Thrombosis With Low-Molecular-Weight Heparin Derivative
Jean-François Vitoux, MD;
Jean-Noël Fiessinger, MD;
Martine Roncato, PhD;
Jean-Marc Pernes, MD;
Philippe Brenot, MD;
Martine Aiach, PhD
Hôpital Broussais Paris
JAMA. 1988;259(8):1180-1181.
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To the Editor.
—Most authors agree with the necessity for long-term antithrombotic therapy after the short-term treatment of deep venous thrombosis (DVT) to prevent thrombus extension and thromboembolic phenomena. However, the duration of this treatment and the nature and dosage of the different drugs are still a matter of debate.1-3 Some properties of low-molecular-weight heparin (LMWH), such as long half-life, good bioavailability, and the low incidence of induced thrombocytopenia, support its use as an alternative in the long-term treatment of DVT.
Study.
—Ten patients (mean age, 59 years) with proximal DVT were included in a prospective study. All the DVTs were recent, as assessed by history and clinical and angiographic criteria. Causes and locations of DVT were varied. Six involved the iliofemoral vein, three involved the superficial femoral vein, and three involved the popliteal vein. The mean ( ± SD) initial phle
bographic score, derived from Arnessen et al,4
. . . [Full Text PDF of this Article]
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