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II. Unstable Angina, Heart Failure, Primary Prevention With Aspirin, and Risk Factor Modification

Salim Yusuf, MRCP DPhil; Janet Wittes, PhD; Lawrence Friedman, MD

JAMA. 1988;260(15):2259-2263.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THIS is the second of a two-part article on the results of randomized trials of treatments designed to reduce mortality or major morbidity in heart disease. Our goal is to summarize the results of trials of common treatments on major outcomes in unstable angina, congestive heart failure, primary prevention with aspirin, and risk factor modification. This summary should provide useful background information against which clinicians must consider other information (eg, patient prognosis, risk of side effects, drug interactions, and specific clinical picture) in making decisions about individual patients. We do not deal in either article with trials of coronary artery bypass graft surgery for stable angina, trials of valve replacement, or congenital heart disease. The risk reductions are based on the odds ratio calculated by the Mantel-Haenszel method as applied to combining data from several trials. When event rates are low, the odds ratio and the relative risk are numerically . . . [Full Text PDF of this Article]

Author Affiliations
From the Clinical Trials Branch (Drs Yusuf and Friedman) and Biostatistics Research Branch (Dr Wittes), Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md.

Footnotes
The opinions expressed in this article are entirely those of the authors and do not necessarily reflect the position of any institution.

Reprint requests to Room 5C-08, Federal Bldg, Clinical Trials Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 (Dr Yusuf).

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