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Eugene S. Hurwitz, MD

JAMA. 1988;260(21):3178-3180.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A syndrome consisting of encephalopathy and fatty metamorphosis of the liver was first described by R. D. K. Reye et al¹ in Australia in 1962 and by George Johnson and coworkers² in the United States in 1963. In contrast to the cases reported by Reye et al—which occurred primarily in infants and young children (66% were 2 years of age) and had no distinct seasonality—the patients first described by Johnson et al were older (between 6 and 13 years of age) and the cases occurred during an outbreak of influenza B in a community in North Carolina. Despite these differences, the similarities of these two descriptions led to the common designation of this clinicopathological entity as Reye-Johnson or Reye's syndrome.

Following its initial description, Reye's syndrome became increasingly recognized in the 1960s and 1970s in the United States as a distinct entity, occurring in association with outbreaks of . . . [Full Text PDF of this Article]

Author Affiliations
Centers for Disease Control Atlanta

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