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Michael A. Bookman, MD; Dan L. Longo, MD; Robert C. Young, MD

JAMA. 1988;260(5):680-683.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SELECTED CASE

CANCER therapy has transformed Hodgkin's disease (HD) from a uniformly fatal to a largely curable disorder. Although most long-term survivors enjoy a normal quality and length of life, complications related to curative treatment can be quite diverse (Figure), as illustrated in the following case report.

A 29-year-old woman who presented with mediastinal stage II-B nodular sclerosing HD in 1978 received urgent chest irradiation due to symptoms of superior vena caval obstruction. Findings from subsequent staging laparotomy were normal, and she was treated with total nodal irradiation (49 Gy) using an expanded mediastinal port. She obtained a clinical complete remission complicated by chronic pulmonary fibrosis, soft-tissue fibrosis, and elevated levels of thyroid-stimulating hormone (TSH). In 1979 she developed pleuritic chest pain, a perihilar mass, and pleural effusion consistent with recurrent HD. Following six cycles of mechlorethamine hydrochloride (Mustargen), vincristine sulfate (Oncovin), procarbazine, and prednisone (MOPP), complicated by febrile neutropenia, . . . [Full Text PDF of this Article]

Author Affiliations
From the Medicine Branch and Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Md.

Footnotes
Presented April 8, 1987, by Robert C. Young, MD, at Clinical Center Grand Rounds, National Institutes of Health.

Reprint requests to Medicine Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Room 12-N-226, Bethesda, MD 20892 (Dr Bookman).

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