This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Marcus M. Reidenberg, MD

JAMA. 1989;261(19):2831-2832.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The awarding of the Nobel Prize in Physiology and Medicine in 1988 to George Hitchings, PhD, DSc, Gertrude B. Elion, MS, and Sir James Black, MB, ChB, and the Lasker Clinical Medicine Research Award to Vincent P. Dole, MD, highlighted some recent advances in pharmacology and therapeutics. Dr Hitchings and Ms Elion received recognition for their work on nucleic acid synthesis that has led to thioguanine, mercaptopurine, azathioprine, allopurinol, cotrimoxazole (sulfamethoxazole with trimethoprim), and acyclovir. Dr Black was recognized for his research on receptor antagonists leading to β-adrenergic blockers and histamine² receptor antagonists. All three were honored for moving drug discovery and development from an era based on natural products to one based on understanding basic biochemical and physiological processes. Dr Dole received his award for his research on narcotic dependence and addiction, including the development of methadone maintenance and acceptance that addiction is a treatable chronic illness. The themes . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?