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Philip Tønnesen, MD
Frederiksberg Hospital Copenhagen, Denmark

JAMA. 1989;261(22):3240.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor. —

In a recently published double-blind, placebo-controlled trial¹ of smoking cessation, 38 heavy smokers received clonidine and 42 received a placebo. There was a significantly better effect with clonidine compared with the placebo on the outcome after 6 months of treatment, with a success rate of 27% in the clonidine group compared with 5% in the placebo group. Clonidine treatment was stopped in 3 (8%) of the 38 subjects owing to sedative effects and treatment was discontinued in 2 (5%) of the 42 placebo-treated subjects (difference not significant). The dose of clonidine was 150 to 300 µg/d. When this study was published, we had almost finished an open clinical trial with clonidine in smoking cessation.

This study comprised 47 subjects (37 women and 10 men) with a median age of 45 years (range, 21 to 70 years). Their cigarette consumption was 20 cigarettes daily (range, 10 . . . [Full Text PDF of this Article]

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