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Conrad B. Blum, MD; Robert I. Levy, MD

JAMA. 1989;261(24):3582-3587.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE EVIDENCE is now in that lowering cholesterol levels reduces the risk of coronary heart disease (CHD). A century of animal data as well as morphological, genetic, and metabolic studies in man point to a strong association between serum cholesterol levels and coronary artery disease. Prospective epidemiologic studies show a graded relationship between serum cholesterol and coronary risk extending to cholesterol levels below 4.14 mmol/L (<160 mg/dL), ie, well into the desirable range for serum cholesterol.¹ Clinical trials performed in man provide the final validation of the cholesterol-atherogenesis connection. In the Lipid Research Clinics Coronary Primary Prevention Trial, over a 7-year period a 12.5% decrease in low-density lipoprotein (LDL) cholesterol levels was associated with a 19% decrease in the incidence of myocardial infarction and CHD death.^2,3 In addition, treatment was associated with a significant reduction in the development of angina, a positive exercise test, and the need for . . . [Full Text PDF of this Article]

Author Affiliations
From Columbia University College of Physicians and Surgeons, New York, NY (Dr Blum); and Sandoz Research Institute, East Hanover, NJ (Dr Levy).

Footnotes
This article is one of a series sponsored by the American Heart Association.

Reprint requests to Sandoz Research Institute, Route 10, East Hanover, NJ 07936 (Dr Levy).

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