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V. Damjanovic, MD, PhD
Sefton General Hospital Liverpool, United Kingdom

JAMA. 1989;261(9):1275.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor. —

Jackson et al¹ recently provided evidence that hemophiliacs with human immunodeficiency virus (HIV) type 1 antibody are actively infected. They studied antibody-positive hemophiliacs who received non-heat-treated factor VIII or IX concentrates. However, cases of HIV seroconversion associated with use of heat-treated lyophilized products also have been reported.² I recently postulated that a majority of such cases have not been infected but have been immunized by preserved viral proteins.³ This is based on experimental evidence of selective inactivation of the infectivity of dried, enveloped viruses by heat⁴ and a theoretical consideration of dry heat inactivation.⁵ Briefly, calculated differences in the energy that governs rates in the dry state for the thermal death of microorganisms (G 89.5 kJ/mol) and protein denaturation (G 126.8 kJ/mol) are significant,⁵ clearly indicating that heating of dry viruses may effectively inactivate them without affecting their . . . [Full Text PDF of this Article]

Footnotes
Edited by Drummond Rennie, MD, Deputy Editor (West).

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