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International Committee for Research in Reproduction

JAMA. 1989;262(2):206-207.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

More than 20 epidemiologic studies have shown no overall association between use of oral contraceptives and breast cancer. Three new studies reviewed by the Food and Drug Administration's committee raised the possibility of an increased relative risk of breast cancer among women less than 45 years of age who present with the disease. One study¹ found a risk ratio of approximately 2, irrespective of duration of oral contraceptive use. The existence of such a large overall risk could hardly have been missed by other studies. Two studies (R. Kay, P. C. Hannafors, unpublished data),² along with certain earlier reports,^3,4 found that women who used oral contraceptives for several years continuously, and possibly before age 25 years or prior to the birth of the first child, had an increased risk of breast cancer below age 45 years. Such an effect, if confirmed, could be a . . . [Full Text PDF of this Article]

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