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James L. Mills, MD, MS
National Institute of Child Health and Human Development Bethesda, Md

George G. Rhoads, MD, MPH
University of Medicine and Dentistry of New Jersey Newark

Joe Leigh Simpson, MD
University of Tennessee Memphis

George C. Cunningham, MD
California Public Health Foundation Berkeley

JAMA. 1990;263(20):2747-2748.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In their article entitled "Multivitamin/Folic Acid Supplementation in Early Pregnancy Reduces the Prevalence of Neural Tube Defects," Milunsky and coauthors¹ suggest that recall bias or undercounting vitamin use in early pregnancy could have resulted in our study's² finding that vitamin and folate supplement use was not associated with a decreased risk for neural tube defects.

We do not consider recall bias a problem in our study, however, because more than half the women who reported supplement use were able to locate the bottle and read us the ingredients, good evidence that the data are accurately reported. Milunsky et al state that most of their subjects did not know their pregnancy outcomes at the time of their interviews. However, it would be important to know how many women, especially those with neural tube defects, knew the results of their maternal serum -fetoprotein screening tests before they were . . . [Full Text PDF of this Article]

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