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Vaginal Prostaglandin E2 and Fatal Amniotic Fluid Embolus
Amir Less, MD;
Shmuel B. Goldberger, MD;
Joelle Bernheim, MD;
Isaac Ben-Nun, MD;
Moshe D. Fejgin, MD
Sapir Medical Center Kfar Saba, Israel
JAMA. 1990;263(24):3259-3260.
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To the Editor.—
Amniotic fluid embolism is a rare but deadly pathological entity that accounts for roughly 10% of all maternal deaths.1,2 We describe a fatal outcome following induction of labor with prostaglandin.
Report of a Case.—
A 37-year-old white woman, gravida 4, para 2, aborta 1, was admitted to our labor ward at 42 weeks' gestation for induction of labor. Her current pregnancy was uncomplicated. Results of a genetic amniocentesis at 16 weeks were normal. At 42 weeks, the patient was admitted for an oxytocin challenge test. All vital signs were normal and the cervix was posterior and uneffaced. The results of her oxytocin challenge test were negative and she was discharged after her contractions stopped.
The following day, she returned complaining of reduction in fetal movements. The nonstress test was reactive and results of physical examination were unchanged. In an attempt to "ripen" the cervix, 3 mg
. . . [Full Text PDF of this Article]
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