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John R. Hughes, MD
University of Vermont Burlington

JAMA. 1990;264(12):1531.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor. —

A little over 1 year ago we published a study that, based on a 1-year follow-up, concluded that nicotine gum did no better than a placebo in helping smokers stop smoking when used with brief physician advice.¹ We noted only one positive study of nicotine vs placebo gum with brief advice.² This study, published in JAMA, used a 6-month follow-up to conclude that using nicotine gum improved smoking cessation. We speculated that this earlier study would fail to find an effect of nicotine gum at 1-year follow-up.

One-year follow-up of the earlier study has now been published and, despite a sample size of 1218, found no benefit of nicotine gum.³ Post hoc analyses suggested that nicotine gum benefited men but not women. Among men, the 1-year abstinence rates were as follows: fixed dosing of nicotine gum, 29%; ad-lib nicotine gum, 22%; ad-lib placebo, . . . [Full Text PDF of this Article]

Footnotes
Edited by Drummond Rennie, MD, Deputy Editor (West), and Don Riesenberg. MD, Senior Editor.

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