This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Richard K. Bernstein, MD
Mamaroneck, NY

JAMA. 1990;264(12):1535-1536.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The recent report by Bantle et al¹ demonstrates for the first time in a controlled fashion what many insulin-using patients have observed since self-monitoring of blood glucose began in 1969. Injections of large boluses of insulin produce highly variable effects on blood glucose levels. Bantle et al found that this variation was nearly doubled when injection sites were rotated. Nevertheless, it was still so great when sites were restricted to the abdomen that near-normal blood glucose levels were not reported.

I take exception to the conclusion of the authors that if their results are confirmed in additional studies, "rotation of the regions used for insulin injections should be replaced by use of a single anatomic region for all injections." Patients who inject large boluses of insulin over and over in the same sites tend to develop subcutaneous deposits of fibrous tissue. They indicate awareness of this . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?