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Robert Ingle, MD
Oregon State University Corvallis

JAMA. 1990;264(14):1811.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I was disturbed by the recent review on hyperbaric oxygen (HBO) therapy.¹ As the former director of several ongoing Air Force human clinical trials of HBO therapy for diabetic wound healing and chronic osteomyelitis, I believe that the article did not sufficiently emphasize the experimental nature of HBO therapy in wound healing.

Further, I found that the review closely followed the advocacy style of the Undersea and Hyperbaric Medical Society,² even down to its inaccurate references (eg, the article by Van Unnik does not say that 250 mm Hg of oxygen tension alters Clostridial alpha toxin production; rather, he concludes that "the production of alpha toxin is inhibited during treatment with oxygen at a pressure of 3 atmospheres absolute but not at a pressure of 2 atmospheres"). The brief review on carbon monoxide poisoning is a further example of this advocacy bias: the only . . . [Full Text PDF of this Article]

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