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Carl F. Needles, MD
Merrick, NY

JAMA. 1990;264(17):2211.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The study by Edmonson et al¹ describes in detail the advent of measles infection in vaccinees. However, their discussion omits two factors that may be contributory.

Measles virus can be immunosuppressive, even in vaccine form. It is well known that prior immunity against the bacillus of tuberculosis can be temporarily lost; in addition, response to varicella virus vaccine is embarrassed if measles vaccine is given first.^2,3

Second, since the present cluster of outbreaks began around 1985, it is possible that the wild virus has mutated, thus causing a secondary vaccine failure.

We seem to be more handicapped in trying to solve this dilemma because we have not developed vehicles for studying the response of cellular immunity to measles vaccination. . . . [Full Text PDF of this Article]

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