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James E. Lewis, PhD
Clinton, Md

JAMA. 1990;264(18):2383-2384.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

7b the Editor. —

In his editorial proclaiming the "myth" of pertussis vaccine encephalopathies, Cherry¹ fails to recognize the paucity of conceptually and methodologically sound research on the insidious neurotoxic effects of the "whole cell" pertussis vaccine. There is little scientific dispute that the pertussis toxin can produce acute local and systemic reactions. The more heated controversy has focused on whether these acute symptoms also involve lasting central nervous system effects, or, as Cherry's referenced studies describe, "permanent brain damage" and "serious neurologic illness."

At a minimum, a conceptually sound cause-and-effect study of hypothesized pertussis vaccine encephalopathies would specify and operationally define the full range of potential sequelae, ie, mild, moderate, and severe pertussis vaccine encephalopathies. An animal experimental paradigm employed by Goh and Pennefather² recently identified a significant neuropathologic mechanism of pertussis toxin, the functional "uncoupling" of G-type proteins in a hippocampal region, effecting disruption of long-term . . . [Full Text PDF of this Article]

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