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William E. Connor, MD

JAMA. 1990;264(21):2797-2798.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In clinical practice, the question of what treatment to employ for the patient with slightly increased plasma cholesterol concentration and mild hypertriglyceridemia frequently arises. Such patients are certainly coronary-prone.^1,2 Not only do they have cholesterol and triglyceride abnormalities, but they also have decreased plasma high-density lipoprotein and increased apoprotein B levels.³ These factors all enhance coronary risk. A variety of treatments are now available for such patients either before or after coronary heart disease has developed. All authorities are agreed that the first line of treatment is dietary.^4,5 These patients are invariably over-weight and are consuming the typical high-fat American diet. Their fat storage is usually abdominal or visceral, especially in the men. This "apple" body configuration predisposes to coronary disease since mobilization of fatty acids from visceral fat moves directly into the liver via the portal vein, where this influx stimulates the overproduction of triglyceride, very . . . [Full Text PDF of this Article]

Author Affiliations
From The Section of Clinical Nutrition and Lipid Metabolism, Department of Medicine, The Oregon Health Sciences University, Portland.

Footnotes
Reprint requests to The Section of Clinical Nutrition and Lipid Metabolism, Department of Medicine, The Oregon Health Sciences University, Portland, OR 97201-3098 (Dr Connor).

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