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Current Concepts

Daniel Steinberg, MD, PhD; Joseph L. Witztum, MD

JAMA. 1990;264(23):3047-3052.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TODAY there is no longer any doubt about the causative relationship between hypercholesterolemia and premature atherosclerosis. The National Institutes of Health Consensus Conference on Lowering Blood Cholesterol Levels¹ and the National Cholesterol Education Program that grew out of it² were the culmination of many years of experimental and clinical research, including, importantly, a number of positive intervention trials that brought to a close the so-called Cholesterol Controversy,³ ie, the controversy as to the importance of hypercholesterolemia as a causative factor in coronary heart disease. Intensive lipid-lowering regimens have been shown not only to slow the progression of coronary atherosclerosis and reduce the risk of coronary events,⁴ but even in some cases to lead to absolute regression.⁵ Best medical practice now calls for appropriate treatment of hypercholesterolemia, and detailed guidelines for treating it are available.^2,6

If we are, then, committed in any case to such . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, University of California—San Diego, La Jolla.

Footnotes
Reprint requests to Department of Medicine, University of California—San Diego, La Jolla, CA 92093 (Dr Steinberg).

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