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Jacques Massé, MD
Hôpital Hôtel-Dieu de Montréal Montréal, Québec

JAMA. 1990;264(9):1101.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Kaufman et al¹ reported that they calculated low-density lipoprotein cholesterol concentration by subtracting the high-density lipoprotein cholesterol concentration and one fifth of the triglyceride concentration from the total cholesterol concentration.² As I have stated elsewhere,³ this equation was developed with conventional units and must be adapted before application with Système International (SI) units: the triglyceride concentration must be divided by 2.18 instead of 5.

Also, the Friedewald formula is valid only if the triglyceride level is below 4.52 mmol/L.^4,5 Kaufman et al¹ excluded specimens only if they were lipemic, but those with triglyceride concentrations between 4.52 and 6.77 mmol/L are not necessarily grossly lipemic, so the absence of lipemia does not mean that the equation can be validly applied in this range. . . . [Full Text PDF of this Article]

Footnotes
Edited by Drummond Rennie, MD, Deputy Editor (West), and Don Riesenberg, MD, Senior Editor.

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