This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (14)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Griffin P. Rodgers, MD

JAMA. 1991;265(16):2097-2101.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SELECTED CASE

A 35-YEAR-OLD man whose sickle cell anemia was first diagnosed at the age of 3 years was referred to the Clinical Center at the National Institutes of Health (NIH), Bethesda, Md, for evaluation and management of his disease. He had a history of frequent vaso-occlusive crises, skin ulcers, and recurrent bacterial pneumonias. He suffered a left hemispheric cerebrovascular accident at the age of 12 years and since then has had a residual seizure disorder. He regularly received transfusions every 3 months from ages 14 to 35 years and at the time of admission to the NIH had an estimated transfusion burden well in excess of 250 U. Other complications of his disease included proliferative sickle retinopathy and cardiomyopathy, which had led to worsening tolerance for exercise. His major complaint, however, was chronic pain in his knees, shins, back, elbows, and shoulders for which he required 4 mg of . . . [Full Text PDF of this Article]

Author Affiliations
From the Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md.

Footnotes
Reprint requests to Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bldg 10, Room 9N-318, National Institutes of Health, Bethesda, MD 20892 (Dr Rodgers).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?