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Jeffrey S. Dover, MD, FRCPC; Kenneth A. Arndt, MD

JAMA. 1991;265(23):3111-3113.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The practice of medicine in the 1990s has been profoundly changed by the human immunodeficiency virus (HIV) epidemic. Current estimates are that more than 1 million individuals in the United States are infected with the HIV, of whom 150 000 have the acquired immunodeficiency syndrome (AIDS). Most patients will develop dermatologic problems during their illness. We will discuss those cutaneous diseases that provide the best clinical clues for diagnosis of HIV infection and about which important findings have been published recently.

Chronic nonhealing perianal herpes simplex virus (HSV) ulcers are an early clue to HIV infection. With increasing immunodeficiency, recurrences of HSV infection may not heal spontaneously but become persistent and progressive. Untreated, the ulcers may become confluent, forming lesions up to 20 cm in diameter, involving half the face or the circumferential skin around the anus. Cytomegalovirus may coexist in these ulcerations or may produce similar lesions independently.¹ . . . [Full Text PDF of this Article]

Author Affiliations
New England Deaconess Hospital, Beth Israel Hospital, and Harvard Medical School, Boston, Mass; Beth Israel Hospital and Harvard Medical School, Boston, Mass

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