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Claude H. Organ, Jr, MD; Vernon J. Henderson, MD

JAMA. 1991;265(23):3172-3175.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Of all the research and clinical accomplishments from our surgical laboratories and hospitals over the last year, we have chosen to concentrate on the molecular biology of cancer, the surgical control of hyperlipidemias, extracorporeal membrane oxygenation, fetal surgery, lung transplantation, and laparoscopic surgery.

Current efforts in molecular biology are primarily directed at understanding genetic alterations relating to neoplasia, in hopes of improving diagnosis, prognosis, and therapy. For example, the deletion of the Rb gene has been found to be associated with retinoblastoma development, and the nature and function of the protein encoded by the gene have been identified.

Colorectal cancer provides an excellent model for current theories of cancer development, which suggest that multiple genetic alterations must occur to allow normal cell transformation to malignancy. Multiple genetic alterations, such as deletions of chromosomes 5, 17, and 18,¹ can be demonstrated in up to 70% of colorectal cancers.² These . . . [Full Text PDF of this Article]

Author Affiliations
University of California, Davis—East Bay, Oakland

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