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Hideto Akama, MD; Shuichi Tsuji, MD
Keio University School of Medicine Tokyo,Japan

JAMA. 1991;265(4):461.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The recent article¹ on aspirin for migraine prophylaxis was done entirely on men. We would like to touch on the relationship among anti-phospholipid antibodies, migraine, and aspirin.

It now appears that antiphospholipid antibodies may be seen in the absence of any collagen vascular disease.² Shuaib and colleagues³ described the presenting features and clinical course of six patients (all women) without underlying collagen vascular diseases, with antiphospholipid antibodies who had migraine as an early and prominent symptom. Thus, the antibodies may play a role in migraine pathogenesis in some individuals.^2,4 Furthermore, aspirin seems effective in preventing migraine due to antiphospholipid antibodies.³ If a study on aspirin prophylaxis for migraine is performed in a female population sample, we expect that a history of recurrent miscarriages or thrombophlebitis will help determine the efficacy of low-dose aspirin. . . . [Full Text PDF of this Article]

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