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HIV TestingState of the Art
Elaine M. Sloand, MD;
Elisabeth Pitt, MA;
Robert J. Chiarello, MD;
George J. Nemo, PhD
JAMA. 1991;266(20):2861-2866.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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TECHNOLOGY for detecting the antibody to human immunodeficiency virus type 1 (HIV-1), the etiologic agent of the acquired immunodeficiency syndrome (AIDS), was first licensed by the Food and Drug Administration (FDA) in 1985. Since then, the spread of the AIDS epidemic from subpopulations, such as male homosexuals, drug abusers sharing contaminated needles, and female prostitutes, to other people with less obvious risk factors has underscored the need for accurate testing to detect infection with HIV-1. The appreciation that people who test positive for HIV-1 can infect others1,2 and the demonstration that infected individuals can benefit from early detection and treatment3-5 have further accentuated this need. Although the first test developed was extremely effective in detecting HIV-1 in patients with AIDS, developing tests for screening healthy people has presented a different challenge. A test that could detect small amounts of HIV-1 early in asymptomatic persons and a confirmatory test
. . . [Full Text PDF of this Article]
Author Affiliations
From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (Drs Sloand and Nemo and Ms Pitt), and the National Institute on Drug Abuse, Rockville, Md (Dr Chiarello).
Footnotes
Reprint requests to National Institutes of Health, Bldg 31, Room 5A21, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Sloand).
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