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James V. Neel, PhD, MD

JAMA. 1991;266(5):698-701.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The genetic implications of human exposures to radiation continue to be very much on the public mind. Interest in the issue was greatly stimulated by the report of Gardner and associates¹ last year. In an effort to understand the excess of childhood leukemia and lymphoma reported in the vicinity of the Sellafield nuclear plant in the West Cumbria district of the United Kingdom, these investigators conducted a case-control study for environmental associations with these diseases. The study identified 52 cases of leukemia, 22 of non-Hodgkin's lymphoma, and 23 of Hodgkin's disease, all occurring under 25 years of age. For each case, up to eight controls were used. Because many of the tests for associations are overlapping, it is difficult to deduce how many independent statistical tests were performed, but it appears to be at least 70. The most significant finding was that the fathers of children who developed leukemia . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Human Genetics, The University of Michigan Medical School, Ann Arbor.

Footnotes
Reprint requests to Department of Human Genetics, The University of Michigan Medical School, Medical Science II M4708, Ann Arbor, Ml 48109-0618 (Dr Neel).

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