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A New Interpretation

Roger C. Bone, MD

JAMA. 1992;267(11):1518-1519.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In this issue of THE JOURNAL, Hotchkiss and Karl¹ review the somewhat paradoxical literature regarding changes in cellular metabolism that occur in sepsis. Their study begins with an apt quotation stating that, the more you look into a complicated problem, the more complicated the problem becomes. This is a virtual understatement when applied to our knowledge of sepsis.² This study is one of scientific interest— one that could turn out to be of great importance in our understanding of the pathophysiology of sepsis and in finding new treatments for the syndrome. When you look at a problem from a direction that challenges conventional wisdom, you may also be getting a view that helps you to finally resolve the problem.

See also p 1503.

The authors advance a provocative theory that challenges the traditional views regarding the occurrence of hypoxia and elevated blood lactate levels in patients with sepsis. . . . [Full Text PDF of this Article]

Author Affiliations
From the Section of Pulmonary Diseases, Department of Internal Medicine, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill.

Footnotes
Reprint requests to Section of Pulmonary Diseases, Department of Internal Medicine, Rush-Presbyterian-St Luke's Medical Center, 1753 W Congress Pkwy, Chicago, IL 60612 (Dr Bone).

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