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The Clinician's Dilemma

Stuart C. Yudofsky, MD

JAMA. 1992;267(13):1826-1827.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since their introduction over a quarter of a century ago, β-adrenergic receptor antagonists (β-blockers) have been among the most commonly prescribed and useful of all medications.¹ Beyond their cardiovascular applications in the treatment of hypertension, arrhythmias, and angina pectoris, and for the prophylaxis of myocardial infarctions in those who have suffered a prior myocardial infarction, β-blockers are currently and increasingly being used for a broad variety of other conditions ranging from performance anxiety, migraine headaches, glaucoma, hyperthyroidism, and hand tremors to the treatment of rage and violent behavior in individuals with brain lesions or injury. Briefly following the introduction of β-blockers, reports appeared in the medical literature associating their use with clinical depression. One of the earliest and most frequently cited articles reported a 50% incidence of depression in patients who had received 120 mg/d of propranolol hydrochloride for periods extending beyond 3 months.²

See also p 1783. . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and the Methodist Hospital, Houston, Tex.

Footnotes
Reprint requests to Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, One Baylor Plaza, Room 115-D, Houston, TX 77030 (Dr Yudofsky).

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