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A.G. Fraser, FRACP; S.B. Rosalki, MD, DSc(Med), FRCP, FRCPath; R.E. Pounder, MA, MD, FRCP
Royal Free Hospital School of Medicine London, England

JAMA. 1992;267(18):2469.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Based on an open study involving only six to eight subjects in each group, DiPadova et at¹ reported that predosing with cimetidine resulted in a 96% mean increase of integrated postprandial alcohol absorption, and that ranitidine resulted in a 41% increase, when alcohol (0.3 g/kg) was imbibed immediately after breakfast.

We have measured blood alcohol concentrations after a range of oral doses of postprandial alcohol (0.15, 0.3, and 0.6 g/kg body weight) in healthy subjects, on the eighth day of dosing with placebo or an H₂-blocker (cimetidine, ranitidine, or famotidine).^2-4 Representative results are shown in the Figure. No significant differences of integrated postprandial blood alcohol concentration was observed after dosing with any of the H₂-blockers. The results of our investigations, which involved placebo-controlled absorption profiles in 92 healthy subjects ingesting ethanol after a standard evening meal, demonstrate no socially or clinically . . . [Full Text PDF of this Article]

Footnotes
Edited by Drummond Rennie, MD, Deputy Editor (West), and Bruce B. Dan, MD, Senior Editor.

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