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Malcolm Rowland, DSc; Stephen Toon, PhD
University of Manchester (England)

JAMA. 1992;267(18):2470.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—DiPadova et al¹ observed an increase in blood alcohol concentration resulting from a single 0.3 g/kg oral dose of ethanol in subjects receiving chronic administration of ranitidine (300 mg/d) and cimetidine (1000 mg/d). Although of interest and worthy of further investigation, we feel that advocation by the authors of prescribing restrictions being applied to these H₂-antagonists based on these findings may be premature and unrealistic.

Such observations should be balanced against the awareness, even by the drinking public, of the dramatic changes in blood alcohol profiles produced by diet and the time at which ethanol is ingested relative to food intake. Wilkinson et al,² for example, observed that dietary variability can produce up to a 300% change in maximum blood alcohol concentration and a 400% change in area under the blood alcohol curve.

This high sensitivity to diet is due to the saturable . . . [Full Text PDF of this Article]

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