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James R. Cooper, MD

JAMA. 1992;267(2):281-282.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The provision of ineffective methadone doses and the premature termination of methadone maintenance treatment have been well-recognized problems for many years in the treatment of opioid addiction. In 1980, 41% of the approximately 64 000 patients receiving methadone maintenance treatment had their dosages stabilized at less than 40 mg/d. Concern over the clinical implications of these treatment data was

See also p 253. a major reason my colleagues and I at the National Institute on Drug Abuse (NIDA) in 1983 asked a group of drug abuse researchers and clinicians to review the wealth of drug abuse treatment research data compiled over the previous 15 years.¹ The issue of appropriate methadone dose was reviewed in detail. The review resulted in a consensus that the dose of methadone should be individualized for each patient and that, for the majority, the most effective dose is between 50 and 100 mg. Furthermore, the . . . [Full Text PDF of this Article]

Author Affiliations
From the Division of Clinical Research, Medical Affairs Branch, Drug Abuse and Mental Health Administration, Rockville, Md.

Footnotes
Reprint requests to Division of Clinical Research, Medical Affairs Branch, Drug Abuse and Mental Health Administration, Rockville, MD 20857 (Dr Cooper).

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