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Ronald B. Herberman, MD

JAMA. 1992;268(20):2935-2939.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE IMMUNE system has the potential to recognize tumors as foreign and thereby effect host resistance against the development and spread of tumors. Strategies to induce or augment immunologic reactivity against tumors have been extensively considered as an approach to cancer therapy. Immunologic assays offer the possibility for sensitive detection of tumors and, therefore, may provide useful tests for detecting and diagnosing cancer and for assessing the prognosis of patients with cancer.

The foundation for tumor immunology was first laid by studies performed mainly with chemically induced sarcomas of inbred mice, which demonstrated that tumor-bearing individuals develop specific immunity to tumor antigens.¹ Since these in vivo studies were performed, a large body of in vitro evidence supporting the concept of tumor-associated antigens (TAAs) and of humoral and cell-mediated immunity against tumors in experimental animals and in humans has developed.

BASIC SCIENCE OF TUMOR IMMUNOLOGY

Immune Mechanisms Involved in Reactivity . . . [Full Text PDF of this Article]

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