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Immunomodulation and Immunotherapy

John W. Hadden, MD; David L. Smith, MD

JAMA. 1992;268(20):2964-2969.

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IMMUNOPHARMACOLOGY involves the study of the regulation of the immune system by pharmacological agents and the development of methods to selectively modify immune function to treat human disease. The delineation of the cellular immune system and the mechanisms of allograft reaction discovered in the early 1960s brought immunosuppression for transplantation and for selected use in autoimmune disease. In the last 15 years, the demonstration of the prevalence of cellular immune defects in cancer, aging, autoimmunity, and infectious diseases has generated interest in the development of immunotherapeutic agents. This chapter provides a brief introduction to immunosuppression and immunotoxicology with emphasis on recent developments in preclinical immunopharmacology and experimental immunotherapeutics.

IMMUNOSUPPRESSIVE THERAPY

A variety of immunosuppressive agents and procedures have been found to be useful in the treatment of autoimmune disease¹ as well as organ transplantation² (Table 24-1). These agents are extensively used in cancer therapy primarily because of their . . . [Full Text PDF of this Article]

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