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Steven E. Carlson
Sunnyvale (Calif) Medical Clinic

JAMA. 1992;268(22):3196.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—I read with interest the article by Carter et al¹ regarding prostate-specific antigen (PSA) levels in men with and without prostate disease. I take issue, however, with the Editorial by Oesterling,² which advocated the addition of PSA testing to digital rectal examination (DRE) for generalized screening to detect prostate cancer.

Catalona et al³ have published the only study that attempts to evaluate the use of PSA tests in a screening population. This study has received significant criticism because patients from the screening group with normal PSA levels did not have biopsies; thus, sensitivity and specificity could not be determined. The study by Carter et al¹ suffered from a similar flaw; the control group did not receive biopsies, and thus, we do not know how many of the patients presumed not to have prostate cancer actually did have it. To date, there has been no . . . [Full Text PDF of this Article]

Footnotes
Edited by Drummond Rennie, MD. Deputy Editor (West), and Bruce B. Dan, MD, Senior Editor.

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