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David R. Cox, MD, PhD

JAMA. 1992;268(3):368-369.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A number of significant advances in medical genetics over the past year have been a result of early successes of the Human Genome Project, an international effort to construct a map of the human "genetic blueprint." An important goal of the Human Genome Project, which officially began in 1990, is to provide more efficient and cost-effective approaches for identifying human disease genes. However, identification of single genes that play key roles in human disease is a daunting task, given that there are an estimated 100 000 human genes scattered throughout the 3 billion base pairs of DNA that make up the human chromosomes. Over the past year, improvements in the map of the human genome have led to the chromosomal localization of a number of new disease genes,¹ including genes involved in breast cancer,² amyotrophic lateral sclerosis,³ and diabetes.⁴ In addition, advances in technologies that allow . . . [Full Text PDF of this Article]

Author Affiliations
University of California, San Francisco

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