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Gerald R. Cooper, MD, PhD; Gary L. Myers, PhD; S. Jay Smith, MIS
Centers for Disease Control Atlanta, Ga

Robert C. Schlant, MD
Emory University School of Medicine Altanta, Ga

JAMA. 1992;268(8):986.

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In Reply.

—Since early 1990, when suggestions were made that oat bran probably possesses a cholesterol-lowering effect because it replaces dietary fats, numerous researchers have reported experiments in which they found oat bran to have an intrinsic hypocholesterolemic capacity.^1-4 Additional studies have reported that other types of fiber possess a similar intrinsic capacity to lower total and LDL cholesterol. It is timely for Dr Koval to call attention to this recent accumulating information on the inherent cholesterol-lowering effect of oat fiber and to point out that the mechanism of total cholesterol— and LDL cholesterol-lowering is not simply by replacement of dietary saturated fats.

The soluble fraction of β-glucan has been identified as the hypocholesterolemic component in oat cereals. Oat, guar gum, and barley fiber appear to be the most effective fiber sources for lowering blood cholesterol levels in hypercholesterolemic men. Oat bran supplementation can decrease total and LDL cholesterol . . . [Full Text PDF of this Article]

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