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Walter C. Willett, MD
for the Nurses' Health Study Group Harvard School of Public Health Boston, Mass

JAMA. 1993;269(14):1792.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—We cannot understand why Dr Prentice wishes only to dichotomize fat intake into below and above the median, which minimizes the contrast in intake. When the highest categories of fat intake (quintiles except in the study by Howe et al) are compared with the lowest categories, the relative risks were 0.90 in our study (1439 cases), 1.30 in the study by Howe et al (519 cases), and 1.13 in the study by Kushi et al (468 cases). Moreover, two additional large prospective studies have been published subsequent to ours; the corresponding relative risks were 1.08 in the study by van den Brandt et al¹ with 471 cases and 0.99 in the study by Graham et al² with 359 cases. Thus, the prospective studies clearly provide an overall association that is very close to the null value of 1.0 and substantially different from the pooled results from . . . [Full Text PDF of this Article]

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