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J. D. WATSON; F. H. C. CRICK

JAMA. 1993;269(15):1967-1969.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE importance of deoxyribonucleic acid (DNA) within living cells is undisputed. It is found in all dividing cells, largely if not entirely in the nucleus, where it is an essential constituent of the chromosomes. Many lines of evidence indicate that it is the carrier of a part of (if not all) the genetic specificity of the chromosomes and thus of the gene itself. Until now, however, no evidence has been presented to show how it might carry out the essential operation required of a genetic material, that of exact self-duplication.

We have recently proposed a structure¹ for the salt of deoxyribonucleic acid which, if correct, immediately suggests a mechanism for its self-duplication. X-ray evidence obtained by the workers at King's College, London², and presented at the same time, gives qualitative support to our structure and is incompatible with all previously proposed structures³. Though the structure will not . . . [Full Text PDF of this Article]

Author Affiliations
Medical Research Council Unit for the Study of the Molecular Structure of Biological Systems, Cavendish Laboratory, Cambridge

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