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From a Theory of Biology to the Care of Patients

William W. McLendon, MD

JAMA. 1993;269(15):1993-1994.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This issue of THE JOURNAL is a celebration of the 40th anniversary of the publication in the April 25 and May 30,1953, issues ofNature of two short articles by James D. Watson and Francis H. C. Crick.^1,2 The first proposed "a radically different structure for the salt of deoxyribose nucleic acid" (DNA) and concluded with the statement, "It has not escaped our notice that the specific pairing [of the purine and pyrimidine bases] we have postulated immediately suggests a possible copying mechanism for the genetic material." In the second article they expand on the "genetical implications" of their proposed double helix structure for DNA. While they recognized that many details remained to be discovered, they suggested that the double helix could answer one of the fundamental questions of biology: that is, what happens at the molecular level to provide a template for the accurate replication of genetic information . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Pathology and Division of Laboratory Medicine, University of North Carolina, Chapel Hill.

Footnotes
Reprint requests to Department of Pathology, University of North Carolina, CB# 7525, Chapel Hill, NC 27599-7525 (Dr McLendon).

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