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Marian G. Michaels, MD, MPH; Joel Frader, MD; John Armitage, MD

JAMA. 1993;269(3):401-403.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE Dr Christian Barnard performed the first adult heart transplant in 1967, this procedure has evolved into a lifesaving surgery for many people with end-stage cardiac function. The first efforts at neonatal heart transplantation were undertaken in 1967 and 1968.^1,2 Both of the infants died within a few hours, temporarily dampening enthusiasm for this procedure in the neonate. In the 1980s, with the advent of improved immunosuppression, solid-organ transplantation became a more feasible treatment for end-stage organ disorders, and interest in neonatal cardiac transplantation was renewed. In the United States, the number of cardiac transplants performed in children less than 1 year of age rose from two in 1984 to 82 in 1990.³ By 1989, surgeons had performed pediatric cardiac transplantation in 61 centers.⁴ Survival with 4 to 40 months of follow-up ranges between 63% and 84%.^5-7 Evaluations to date show normal growth and development of . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Pediatrics (Drs Michaels and Frader), the Center for Medical Ethics (Dr Frader), and the Department of Surgery (Drs Armitage and Michaels), University of Pittsburgh (Pa) School of Medicine, and the Children's Hospital of Pittsburgh.

Footnotes
Reprints not available.

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