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Joel Gelernter, MD; Neil Risch, PhD
Yale University School of Medicine New Haven, Conn

David Goldman, MD
National Institute on Alcohol Abuse and Alcoholism Bethesda, Md

JAMA. 1993;270(13):1547-1548.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—We still believe that no association between the Al allele at DRD₂ and alcoholism has been proven and that there are better, more conservative explanations for the accumulated data than a physiologically important association. Several of the points raised by Drs Noble and Blum derive from misreadings of our article and from making statements about issues previously addressed by us in detail, without attempts to answer our arguments directly. For example, we did not exclude their first study from our analyses. To the contrary, in an analysis considering the data about alcoholics from their group separately, we demonstrated that their results were significantly different from those obtained by all other researchers.¹

Noble and Blum state that "it is important that association studies for alcoholics should use for comparison controls carefully screened for alcoholism." The statement quoted is not, however, an accurate statement about design of association . . . [Full Text PDF of this Article]

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