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Touchstones for Understanding the Inflammatory Myopathies

Frederick W. Miller, MD, PhD

JAMA. 1993;270(15):1846-1849.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SELECTED CASE

A 27-year-old stonemason, who was previously well, had acute onset of weakness, stiffness, and pain in the proximal arm, leg, and back muscles. A week later low-grade evening fevers, diffuse swelling of his extremities and face, and a bluish rash over his eyelids developed; 2 weeks after that, he noticed shortness of breath, dysphagia, and a thickening of his voice. During the next several days, his condition deteriorated rapidly, with increasing shortness of breath and cyanosis, and he died of a presumed pulmonary arrest.

Autopsy showed firm, fluid-filled lungs, splenomegaly, and swollen proximal muscles; the distal muscles, eye muscles, and tongue muscles were spared. Histopathologic examination showed a focal round-cell infiltration permeating the interstitium of the affected muscles and muscle cells in various stages of degeneration. No microorganisms were seen.

THE IDIOPATHIC INFLAMMATORY MYOPATHIES

With the publication of this case over 100 years ago,¹ Professor Hans Unverricht . . . [Full Text PDF of this Article]

Author Affiliations
From the Laboratory of Molecular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Md.

Footnotes
Reprint requests to the Center for Biologics Evaluation and Research, N29, Room 507, HFM-521, Food and Drug Administration, Bethesda, Md 20892 (Dr Miller).

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